The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study.

ABSTRACT:

Background

Accumulating evidence shows that dysregulation of intestinal flora is associated with inflammatory skin diseases, specifically atopic dermatitis (AD), psoriasis (PSO), and rosacea (ROS). However, the causality is still unclear.

Objectives

To study the underlying causality between gut microbiota (GM) and AD, PSO, and ROS, a bi-directional two-sample Mendelian randomization (2SMR) analysis was conducted.

Methods

Summary statistics of gut microbiota, AD, PSO, and ROS were extracted from large-scale genome-wide association studies (GWASs). In 2SMR analysis, in addition to the inverse variance weighted as the principal method for evaluating causal association, four different methods were also used. Sensitivity analysis and reverse 2SMR study were implemented to

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC10869565 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature