Contemporary preclinical mouse models for pediatric rhabdomyosarcoma: from bedside to bench to bedside.

ABSTRACT:

Background

Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue malignancy, characterized by high clinicalopathological and molecular heterogeneity. Preclinical in vivo models are essential for advancing our understanding of RMS oncobiology and developing novel treatment strategies. However, the diversity of scholarly data on preclinical RMS studies may challenge scientists and clinicians. Hence, we performed a systematic literature survey of contemporary RMS mouse models to characterize their phenotypes and assess their translational relevance.

Methods

We identified papers published between 01/07/2018 and 01/07/2023 by searching PubMed and Web of Science databases.

Results

Out of 713 records screened, 118 studies (26.9%) were included in the qualita

SUBMITTER: Martynov I 

PROVIDER: S-EPMC10869630 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature