Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma.

ABSTRACT:

Introduction

Several studies have linked increased risk of osteosarcoma with tall stature, high birthweight, and early puberty, although evidence is inconsistent. We used genetic risk scores (GRS) based on established genetic loci for these traits and evaluated associations between genetically inferred birthweight, height, and puberty timing with osteosarcoma.

Methods

Using genotype data from two genome-wide association studies, totaling 1039 cases and 2923 controls of European ancestry, association analyses were conducted using logistic regression for each study and meta-analyzed to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses were conducted by case diagnosis age, metastasis status, tumor location, tumor histology, and presence of

SUBMITTER: Gianferante DM 

PROVIDER: S-EPMC10869637 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature