New risk stratification for adjuvant nivolumab for high-risk muscle-invasive urothelial carcinoma.

ABSTRACT:

Objectives

We aim to evaluate the risk of recurrence after neoadjuvant chemotherapy followed by radical cystectomy, particularly in ypT2 disease in patients with urothelial carcinoma, because it is not clear if all eligible patients with high-risk muscle-invasive urothelial carcinoma should be treated with adjuvant nivolumab.

Materials and methods

We analysed the radiological and clinicopathological features, including cT and ypT stages, of 197 patients who had undergone two to four cycles of cisplatin-based neoadjuvant chemotherapy and radical cystectomy without adjuvant chemotherapy. We stratified the risk of postoperative recurrence by these factors.

Results

The median observation period was 29.6 (interquartile range, 11.4-71.7) months, and disease recurrence was o

SUBMITTER: Saito T 

PROVIDER: S-EPMC10869665 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature