Pathophysiological profile of non-ventilated lung injury in healthy female pigs undergoing mechanical ventilation.

ABSTRACT:

Background

Lung regions excluded from mechanical insufflation are traditionally assumed to be spared from ventilation-associated lung injury. However, preliminary data showed activation of potential mechanisms of injury within these non-ventilated regions (e.g., hypoperfusion, inflammation).

Methods

In the present study, we hypothesized that non-ventilated lung injury (NVLI) may develop within 24 h of unilateral mechanical ventilation in previously healthy pigs, and we performed extended pathophysiological measures to profile NVLI. We included two experimental groups undergoing exclusion of the left lung from the ventilation with two different tidal volumes (15 vs 7.5 ml/kg) and a control group on bilateral ventilation. Pathophysiological alteration including lung collapse,

SUBMITTER: Spinelli E 

PROVIDER: S-EPMC10869686 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature