Deciphering the impact of microbial interactions on COPD exacerbation: An in-depth analysis of the lung microbiome.

ABSTRACT: In microbiome studies, the diversity and types of microbes have been extensively explored; however, the significance of microbial ecology is equally paramount. The comprehension of metabolic interactions among the wide array of microorganisms in the lung microbiota is indispensable for understanding chronic pulmonary disease and for the development of potent treatments. In this investigation, metabolic networks were simulated, and ecological theory was employed to assess the diagnosis of COPD, subsequently suggesting innovative treatment strategies for COPD exacerbation. Lung sputum 16S rRNA paired-end data from 112 COPD patients were utilized, and a supervised machine-learning algorithm was applied to identify taxa associated with sex and mortality. Subsequently, an OTU table with Greenge

SUBMITTER: Taherkhani H 

PROVIDER: S-EPMC10869780 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature