Cancer-related cells and oncosomes in the liquid biopsy of pancreatic cancer patients undergoing surgery.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of less than 10% due to its late diagnosis, rapid metastasis, and chemotherapeutic resistance. For a small proportion (10-20%) of early-stage patients however, surgical resection of the pancreatic tumor offers the best chance for survival but the effect of surgery on disease dissemination is unknown. The primary objective of this study was to characterize cellular and acellular blood-based analytes in portal and peripheral blood before pancreatic manipulation, during tumor dissection and immediately after surgical resection to determine the effects of the surgery. This study used the non-enriching third generation High-Definition Single Cell Assay (HDSCA3.0) workflow to investigate heterogeneous circulating rare cell pop

SUBMITTER: Shishido SN 

PROVIDER: S-EPMC10869814 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature