A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage.

ABSTRACT: This communication presents a mathematical mechanism-based model of the regenerating liver after drug-induced pericentral lobule damage resolving tissue microarchitecture. The consequence of alternative hypotheses about the interplay of different cell types on regeneration was simulated. Regeneration dynamics has been quantified by the size of the damage-induced dead cell area, the hepatocyte density and the spatial-temporal profile of the different cell types. We use deviations of observed trajectories from the simulated system to identify branching points, at which the systems behavior cannot be explained by the underlying set of hypotheses anymore. Our procedure reflects a successful strategy for generating a fully digital liver twin that, among others, permits to test perturbations fro

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10869925 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature