Quantification of Enteric Dysfunction in Cystic Fibrosis: Inter- and Intraindividual Variability.

ABSTRACT:

Objectives

To test the utility of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and determine whether intraindividual variations in these measures are repeatable over short intervals and whether interindividual variations correlate with clinical outcomes.

Study design

We performed a cross-sectional, limited longitudinal study of children with CF aged 1-21 years who provided blood and stool samples at 2 or 3 visits, 2 weeks and 3 months apart, which were assayed for markers of intestinal inflammation (fecal calprotectin [fCal], lipocalin-2 [fLcn2], neopterin), and permeability (plasma lipopolysaccharide [LPS] antibodies, LPS-binding protein) by enzyme immunoassays. Control specimens were obtained from children without CF who had undergone esophag

SUBMITTER: Duckworth LA 

PROVIDER: S-EPMC10869934 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature