Day-to-day sleep variability with Alzheimer's biomarkers in at-risk elderly.

ABSTRACT:

Introduction

Measuring day-to-day sleep variability might reveal unstable sleep-wake cycles reflecting neurodegenerative processes. We evaluated the association between Alzheimer's disease (AD) fluid biomarkers with day-to-day sleep variability.

Methods

In the PREVENT-AD cohort, 203 dementia-free participants (age: 68.3 ± 5.4; 78 males) with a parental history of sporadic AD were tested with actigraphy and fluid biomarkers. Day-to-day variability (standard deviations over a week) was assessed for sleep midpoint, duration, efficiency, and nighttime activity count.

Results

Lower cerebrospinal fluid (CSF) ApoE, higher CSF p-tau181/amyloid-β (Aβ)₄₂, and higher plasma p-tau231/Aβ₄₂ were associated with higher variability of sleep midpoint, sleep durat

SUBMITTER: Baril AA 

PROVIDER: S-EPMC10870017 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature