Sequential-Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis.

ABSTRACT: Achieving hemostasis effectively is essential for surgical success and excellent patient outcomes. However, it is challenging to develop hemostatic adhesives that are fast-acting, strongly adherent, long-lasting, and biocompatible for treating hemorrhage. In this study, a sequential crosslinking fibrin glue (SCFG) is developed, of which the first network of the fibrin glue forms in situ within 2 s to act as an initial physical barrier and locks the gelatin methacryloyl precursor for tight construction of the second network to enhance wet adhesion and durability for tissues covered with blood. The sequential crosslinking glue can provide large pressures (≈280 mmHg of burst pressure), makes strong (38 kPa of shear strength) and tough (≈60 J m^-2 of interfacial toughness) interfaces

SUBMITTER: Yu L 

PROVIDER: S-EPMC10870078 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature