Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders.

ABSTRACT: Genome-wide association studies (GWASs) have uncovered susceptibility loci associated with psychiatric disorders such as bipolar disorder (BP) and schizophrenia (SCZ). However, most of these loci are in non-coding regions of the genome, and the causal mechanisms of the link between genetic variation and disease risk is unknown. Expression quantitative trait locus (eQTL) analysis of bulk tissue is a common approach used for deciphering underlying mechanisms, although this can obscure cell-type-specific signals and thus mask trait-relevant mechanisms. Although single-cell sequencing can be prohibitively expensive in large cohorts, computationally inferred cell-type proportions and cell-type gene expression estimates have the potential to overcome these problems and advance mechanistic studie

SUBMITTER: Boltz T 

PROVIDER: S-EPMC10870131 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature