Phase separation of multicomponent peptide mixtures into dehydrated clusters with hydrophilic cores.

ABSTRACT: Phase separation of biomolecules underlies the formation and regulation of various membraneless condensates in cells. How condensates function reliably while surrounded by heterogeneous and dynamic mixtures of biomolecular components with specific and nonspecific interactions is yet to be understood. Studying multicomponent biomolecular mixtures with designer peptides has recently become an attractive avenue for learning about physicochemical principles governing cellular condensates. In this work, we employed long-timescale atomistic simulations of multicomponent tripeptide mixtures with all residue substitutions to illuminate the nature of direct and water-mediated interactions in a prototypical cellular condensate environment. We find that peptide mixtures form clusters with inverse hyd

SUBMITTER: Brown WH 

PROVIDER: S-EPMC10870168 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature