Antibacterial activity of isopropoxy benzene guanidine against Riemerella anatipestifer.

ABSTRACT: Introduction: Riemerella anatipestifer (R. anatipestifer) is an important pathogen in waterfowl, leading to substantial economic losses. In recent years, there has been a notable escalation in the drug resistance rate of R. anatipestifer. Consequently, there is an imperative need to expedite the development of novel antibacterial medications to effectively manage the infection caused by R. anatipestifer. Methods: This study investigated the in vitro and in vivo antibacterial activities of a novel substituted benzene guanidine analog, namely, isopropoxy benzene guanidine (IBG), against R. anatipestifer by using the microdilution method, time-killing curve, and a pericarditis model. The possible mechanisms of these activities were explo

SUBMITTER: Lu Y 

PROVIDER: S-EPMC10870170 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature