Circulating Leukocyte Subsets Before and After a Breast Cancer Diagnosis and Therapy.

ABSTRACT:

Importance

Changes in leukocyte composition often precede chronic disease onset. Patients with a history of breast cancer (hereinafter referred to as breast cancer survivors) are at increased risk for subsequent chronic diseases, but the long-term changes in peripheral leukocyte composition following a breast cancer diagnosis and treatment remain unknown.

Objective

To examine longitudinal changes in peripheral leukocyte composition in women who did and did not develop breast cancer and identify whether differences in breast cancer survivors were associated with specific treatments.

Design, setting, and participants

In this prospective cohort study, paired blood samples were collected from 2315 women enrolled in The Sister Study, a US-nationwide prospective cohort stud

SUBMITTER: Kresovich JK 

PROVIDER: S-EPMC10870180 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature