Presence of Copy Number Variants Associated With Esotropia in Patients With Exotropia.

ABSTRACT:

Importance

Strabismus is a common ocular disorder of childhood. There is a clear genetic component to strabismus, but it is not known if esotropia and exotropia share genetic risk factors.

Objective

To determine whether genetic duplications associated with esotropia are also associated with exotropia.

Design, setting, and participants

This was a cross-sectional study conducted from November 2005 to December 2023. Individuals with constant or intermittent exotropia of any magnitude or a history of surgery for exotropia were recruited from pediatric ophthalmic practices. Data were analyzed from March to December 2023.

Exposure

Genetic duplication.

Main outcomes and measures

Presence of genetic duplications at 2p11.2, 4p15.2, and 10q11.22 assessed by digita

SUBMITTER: Martinez Sanchez M 

PROVIDER: S-EPMC10870223 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature