Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA.

ABSTRACT:

Background

Trimethoprim/sulfamethoxazole is a synthetic antibiotic combination recommended for the treatment of complicated non-typhoidal Salmonella infections in humans. Resistance to trimethoprim/sulfamethoxazole is mediated by the acquisition of mobile genes, requiring both a dfr gene (trimethoprim resistance) and a sul gene (sulfamethoxazole resistance) for a clinical resistance phenotype (MIC ≥4/76 mg/L). In 2017, the CDC investigated a multistate outbreak caused by a Salmonella enterica serotype Heidelberg strain with trimethoprim/sulfamethoxazole resistance, in which sul genes but no known dfr genes were detected.

Objectives

To characterize and describe the molecular mechanism of trimethoprim resistance in a Salmonella Heidelberg outbreak isolate.

Methods

Illum

SUBMITTER: Tagg KA 

PROVIDER: S-EPMC10870229 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature