Bleeding related to oral anticoagulants: Trends in US emergency department visits, 2016-2020.

ABSTRACT:

Background

Clinical trials suggest lower rates of major bleeding with direct-acting oral anticoagulants (DOACs) than with warfarin, but anticoagulant-related bleeding remains one of the most common outpatient adverse drug events.

Methods

We estimated the number of emergency department (ED) visits and subsequent hospitalizations for oral anticoagulant-related bleeding in 2016-2020 based on active surveillance in a nationally representative, size-stratified probability sample of 60 U.S. hospitals. We estimated rates of ED visits using a nationally-projected retail prescription dispensing database.

Results

Based on 19,557 cases, oral anticoagulant-related bleeding resulted in an estimated 1,270,259 (95 % Confidence Interval [CI], 644,686-1,895,832) ED visits for the five

SUBMITTER: Geller AI 

PROVIDER: S-EPMC10870325 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature