In Vitro Hemoglobin Binding and Molecular Docking of Synthesized Chitosan-Based Drug-Carrying Nanocomposite for Ciprofloxacin-HCl Drug Delivery System.

ABSTRACT: Understanding the intermolecular interactions between antibiotic drugs and hemoglobin is crucial in biological systems. The current study aimed to investigate the preparation of chitosan/polysorbate-80/tripolyphosphate (CS-PS/TPP) nanocomposite as a potential drug carrier for Ciprofloxacin-HCl drug (CFX), intended for controlled release formulation and further used to interact with bovine hemoglobin. Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis-differential thermal analysis (TGA-DTA), scanning electron microscopy (SEM), dynamic light scattering (DLS), and X-ray diffraction analyses were used to characterize the CS-PS/TPP nanocomposite and its CFX-loaded nanocomposite. The second series of biophysical properties were performed on the Ciprofloxacin-loaded CS-PS

SUBMITTER: Manea YK 

PROVIDER: S-EPMC10870405 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature