ADARs regulate cuticle collagen expression and promote survival to pathogen infection.

ABSTRACT:

Background

In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deaminase that act on RNA (ADAR) family of RNA-binding proteins has been reported to influence innate immunity in metazoans. However, studies on the susceptibility of ADAR mutant animals to infection are largely lacking.

Results

Here, by analyzing adr-1 and adr-2 null mutants in well-established slow-killing assays, we find that both Caenorhabditis elegans ADARs are important for organismal survival to gram-negative and gram-positive bacteria, all of which are pathogenic to humans. Furthermore, our high-throughput sequencing and genetic analys

SUBMITTER: Dhakal A 

PROVIDER: S-EPMC10870475 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature