Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer.

ABSTRACT: All-trans retinoic acid (ATRA) is the most relevant and functionally active metabolite of Vitamin-A. From a therapeutic standpoint, ATRA is the first example of pharmacological agent exerting its anti-tumor activity via a cell differentiating action. In the clinics, ATRA is used in the treatment of Acute Promyelocytic Leukemia, a rare form of myeloid leukemia with unprecedented therapeutic results. The extraordinary effectiveness of ATRA in the treatment of Acute Promyelocytic Leukemia patients has raised interest in evaluating the potential of this natural retinoid in the treatment of other types of neoplasias, with particular reference to solid tumors.The present article provides an overview of the available pre-clinical and clinical studies focussing on ATRA as a therapeutic agent in th

SUBMITTER: Caricasulo MA 

PROVIDER: S-EPMC10870483 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature