Stress-induced hyperglycemia is associated with the mortality of thrombotic thrombocytopenic purpura patients.

ABSTRACT:

Background

Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with a rapid progression and high mortality rate. We aimed to explore early risk factors for mortality in patients with TTP.

Methods

We conducted a retrospective analysis of 42 TTP patients that were admitted to our hospital between 2000 and 2021, with a median age of 49 (29-63) years. Risk factors for mortality were evaluated using multivariate logistic regression. Receiver operating characteristic curve analysis was used to determine the cut-off value of glucose for predicting mortality in patients, which was validated by comparison to a similar cohort in the published literature.

Results

Elevated glucose level and reduced red blood cells (RBC) counts were risk factors for mort

SUBMITTER: Hu L 

PROVIDER: S-EPMC10870494 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature