Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is a prevalent complication of diabetes and the leading cause of end-stage renal disease. Recent evidence suggests that total flavonoids of Astragalus (TFA) has promising effects on diabetes; however, its influence on DKD and the underlying mechanism remains unclear.

Methods

In this study, we induced the DKD model using streptozotocin (STZ) in male C57BL/6J mice and utilized glomerular endothelial cell (GEC) lines for in vitro investigations. We constructed a network pharmacology analysis to understand the mechanism of TFA in DKD. The mechanism of TFA action on DKD was investigated through Western blot analysis and multi-immunological methods.

Results

Our findings revealed that TFA significantly reduced levels of urinary albumi

SUBMITTER: Liu PY 

PROVIDER: S-EPMC10870499 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature