Association of per- and polyfluoroalkyl substances (PFAS) with periodontitis: the mediating role of sex hormones.

ABSTRACT:

Objectives

To investigate the association between serum per- and polyfluoroalkyl substances (PFAS) and periodontitis, and further explore the possible mediating role of sex hormones in this association.

Methods

We extracted data from National Health and Nutrition Examination Survey (NHANES) 2009-2014. Univariable and multivariable logistic regression models were performed to investigate the association between serum levels of seven PFASs and periodontitis. Bayesian kernel machine regression (BKMR) was conducted to assess the joint effect of PFASs in mixtures. Mediation analyses were used to explore the potential mediating role of sex hormones.

Results

Participants with periodontitis had higher concentrations of serum perfluorooctane sulfonate (PFOS) and perfluorononan

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10870532 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature