Effects of topical application of resveratrol on tight junction barrier and antimicrobial compound production in lactating goat mammary glands.

ABSTRACT: In mammary glands, the formation of less-permeable tight junctions (TJs) and the production of antimicrobial compounds like lactoferrin and defensins are important for preventing mastitis. Resveratrol, a polyphenol contained in red grapes, is known to protect mammary epithelial cells (MECs) from oxidative stress; however, oral administration of resveratrol causes a decrease in certain biological processes through conjugation and metabolic conversion. In this study, we determined the beneficial effects of resveratrol on TJs and antimicrobial compounds in cultured goat MECs by adding it to the medium, and in lactating goat mammary glands by topical application for percutaneous absorption. TJ barrier function was evaluated by transepithelial resistance and expression or localization pattern o

SUBMITTER: Tsugami Y 

PROVIDER: S-EPMC10870570 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature