Investigating the relationship between carbapenemase production and biofilm formation in Klebsiella pneumoniae clinical isolates.

ABSTRACT:

Objective

Carbapenemase production and biofilm formation in K. pneumoniae are crucial factors influencing the pathogenicity and antibiotic resistance of this bacterium. This study investigated the interplay between carbapenemase production and biofilm formation in K. pneumoniae clinical isolates.

Results

The distribution of biofilm-forming ability significantly differed between carbapenemase-producing (CP-Kp) (n = 52) isolates and carbapenemase-nonproducing (CN-Kp) isolates (n = 37), suggesting a potential link between carbapenemase production and biofilm formation. All the bla_NDM-1-harbouring isolates demonstrated biofilm formation, with varying levels classified as strong (33.33%), moderate (22.22%), or weak (44.45%). bla_NDM-1 and bla_KPC-co

SUBMITTER: El Naggar NM 

PROVIDER: S-EPMC10870607 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature