Particulate matter from car exhaust alters function of human iPSC-derived microglia.

ABSTRACT:

Background

Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer's disease. Inhaled components of PM may directly invade the brain via the olfactory route, or act through peripheral system responses resulting in inflammation and oxidative stress in the brain. Microglia are the immune cells of the brain implicated in the progression of neurodegenerative diseases. However, it remains unknown how PM affects live human microglia.

Results

Here we show that two different PMs derived from exhausts of cars running on EN590 diesel or compressed natural g

SUBMITTER: Jantti H 

PROVIDER: S-EPMC10870637 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature