Association of structural connectivity with functional brain network segregation in a middle-aged to elderly population.

ABSTRACT:

Introduction

The deterioration of white matter pathways is one of the hallmarks of the ageing brain. In theory, this decrease in structural integrity leads to disconnection between regions of brain networks and thus to altered functional connectivity and a decrease in cognitive abilities. However, in many studies, associations between structural and functional connectivity are rather weak or not observed at all. System segregation, defined as the extent of partitioning between different resting state networks has increasingly gained attention in recent years as a new metric for functional changes in the aging brain. Yet there is a shortage of previous reports describing the association of structural integrity and functional segregation.

Methods

Therefore, we used a large a l

SUBMITTER: Schulz M 

PROVIDER: S-EPMC10870644 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature