Particulate matter 2.5 causally increased genetic risk of autism spectrum disorder.

ABSTRACT:

Background

Growing evidence suggested that particulate matter (PM) exhibit an increased risk of autism spectrum disorder (ASD). However, the causal association between PM and ASD risk remains unclear.

Methods

We performed two-sample Mendelian randomization (MR) analyses, using instrumental variables (IVs) sourced from the largest genome-wide association studies (GWAS) databases. We employed three MR methods: inverse-variance weighted (IVW), weighted median (WM), and MR-Egger, with IVW method serving as our primary MR method. Sensitivity analyses were performed to ensure the stability of these findings.

Results

The MR results suggested that PM_2.5 increased the genetic risk of ASD (β = 2.41, OR = 11.13, 95% CI: 2.54-48.76, P < 0.01), and similar result was fo

SUBMITTER: Jin T 

PROVIDER: S-EPMC10870670 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature