The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis.

ABSTRACT:

Aim

Cannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the effect of cannabinoid receptor modulation on kidney disease.

Methods

PubMed, Web of Science databases, and EMBASE were searched. Articles selection, data extraction and quality assessment were independently performed by two investigators. The SYRCLE's RoB tool was used to assess the risk of study bias, and pooled SMD using a random-effect model and 95% CIs were calculated. Subgroup analyses were conducted in preselected subgroups, and publication bias was evaluated. We compared the effects of CB1 and CB2 antagonists and/or knockout and agonists and/or genetic regulation on renal function, blood glucose levels, body weight, and patholog

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10870675 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature