Exact and Ubiquitous Condition for Solid-State Deracemization in Vitro and in Nature.

ABSTRACT: Solid-state deracemization is the amplification of an enantiomeric excess in suspensions of conglomerate-forming chiral compounds. Although numerous chemical and biochemical compounds deracemize, its governing mechanism has remained elusive. We introduce a novel formulation of the classical population-based model of deracemization through temperature cycles to prove that suspensions deracemize whenever a simple and ubiquitous condition is met: crystal dissolution must be faster than crystal growth. Such asymmetry is a known principle of crystallization, hence explaining the generality of deracemization. Through both experiments and a theoretical analysis, we demonstrate that this condition applies even for very small temperature cycles and for random temperature fluctuations. These finding

SUBMITTER: Deck LT 

PROVIDER: S-EPMC10870780 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature