ROS-Responsive 4D Printable Acrylic Thioether-Based Hydrogels for Smart Drug Release.

ABSTRACT: Reactive oxygen species (ROS) play a key role in several biological functions like regulating cell survival and signaling; however, their effect can range from beneficial to nondesirable oxidative stress when they are overproduced causing inflammation or cancer diseases. Thus, the design of tailor-made ROS-responsive polymers offers the possibility of engineering hydrogels for target therapies. In this work, we developed thioether-based ROS-responsive difunctional monomers from ethylene glycol/thioether acrylate (EG_nSA) with different lengths of the EG_n chain (n = 1, 2, 3) by the thiol-Michael addition click reaction. The presence of acrylate groups allowed their photopolymerization by UV light, while the thioether groups conferred ROS-responsive

SUBMITTER: Regato-Herbella M 

PROVIDER: S-EPMC10870821 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature