Design, synthesis, and inhibitory activity of hydroquinone ester derivatives against mushroom tyrosinase.

ABSTRACT: Tyrosinase is a widely distributed copper-containing enzyme found in various organisms, playing a crucial role in the process of melanin production. Inhibiting its activity can reduce skin pigmentation. Hydroquinone is an efficient inhibitor of tyrosinase, but its safety has been a subject of debate. In this research, a scaffold hybridization strategy was employed to synthesize a series of hydroquinone-benzoyl ester analogs (3a-3g). The synthesized compounds were evaluated for their inhibitory activity against mushroom tyrosinase (mTyr). The results revealed that these hydroquinone-benzoyl ester analogs exhibited inhibitory activity against mTyr, with compounds 3a-3e displaying higher activity, with compound 3b demonstrating the highest potency (IC₅₀ = 0.18 ± 0.06 μM). Kinetic s

SUBMITTER: Xie D 

PROVIDER: S-EPMC10870825 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature