Direct targeting of the mouse optic nerve for therapeutic delivery.

ABSTRACT:

Background

Animal models of optic nerve injury are often used to study central nervous system (CNS) degeneration and regeneration, and targeting the optic nerve is a powerful approach for axon-protective or remyelination therapy. However, the experimental delivery of drugs or cells to the optic nerve is rarely performed because injections into this structure are difficult in small animals, especially in mice.

New method

We investigated and developed methods to deliver drugs or cells to the mouse optic nerve through 3 different routes: a) intraorbital, b) through the optic foramen and c) transcranial.

Results

The methods targeted different parts of the mouse optic nerve: intraorbital proximal (intraorbital), intracranial middle (optic-foramen) or intracranial distal (t

SUBMITTER: Mesentier-Louro LA 

PROVIDER: S-EPMC10870831 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature