Large-scale functional network connectivity mediates the associations between lipids metabolism and cognition in type 2 diabetes.

ABSTRACT: Type 2 diabetes (T2D) is associated with dyslipidemia and mild cognitive impairment. This study investigated the relationships between serum lipids metabolism, cognition, and functional connectivity (FC) within and between brain networks in T2D patients. The study included 102 T2D patients and 45 healthy controls who underwent functional magnetic resonance imaging, lipid profile tests, and cognitive assessments. Thirteen functional networks were identified using independent component analysis. The statistical analyses included multivariate analysis of covariance, partial correlation, canonical correlation, and mediation analyses. We found widely reduced between-network FCs in T2D, especially between the ventral sensorimotor network (SMN) and dorsal attention network (DAN) (p = 0.001) and b

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10870959 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature