[¹⁸F]LW223 has low non-displaceable binding in murine brain, enabling high sensitivity TSPO PET imaging.

ABSTRACT: Neuroinflammation is associated with a number of brain diseases, making it a common feature of cerebral pathology. Among the best-known biomarkers for neuroinflammation in Positron Emission Tomography (PET) research is the 18 kDa translocator protein (TSPO). This study aims to investigate the binding kinetics of a novel TSPO PET radiotracer, [¹⁸F]LW223, in mice and specifically assess its volume of non-displaceable binding (V_ND) in brain as well as investigate the use of simplified analysis approaches for quantification of [¹⁸F]LW223 PET data. Adult male mice were injected with [¹⁸F]LW223 and varying concentrations of LW223 (0.003-0.55 mg/kg) to estimate V_ND of [¹⁸F]LW223. Dynamic PET imaging with arterial inpu

SUBMITTER: Knyzeliene A 

PROVIDER: S-EPMC10870961 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature