Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.

ABSTRACT: HOXB13 is a key lineage homeobox transcription factor that plays a critical role in the differentiation of the prostate gland. Several studies have suggested that HOXB13 alterations may be involved in prostate cancer development and progression. Despite its potential biological relevance, little is known about the expression of HOXB13 across the disease spectrum of prostate cancer. To this end, we validated a HOXB13 antibody using genetic controls and investigated HOXB13 protein expression in murine and human developing prostates, localized prostate cancers, and metastatic castration-resistant prostate cancers. We observed that HOXB13 expression increases during later stages of murine prostate development. All localized prostate cancers showed HOXB13 protein expression. Interestingly, lowe

SUBMITTER: Patel RA 

PROVIDER: S-EPMC10871027 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature