<i>Aspergillus fumigatus</i> cytochrome c impacts conidial survival during sterilizing immunity.

ABSTRACT:

Importance

Aspergillus fumigatus can cause a life-threatening infection known as invasive pulmonary aspergillosis (IPA), which is marked by fungus-attributable mortality rates of 20%-30%. Individuals at risk for IPA harbor genetic mutations or incur pharmacologic defects that impair myeloid cell numbers and/or function, exemplified by bone marrow transplant recipients, patients that receive corticosteroid therapy, or patients with chronic granulomatous disease (CGD). However, treatments for Aspergillus infections remain limited, and resistance to the few existing drug classes is emerging. Recently, the World Health Organization classified A. fumigatus as a critical priority fungal pathogen. Our cell death research identifies an important aspect of fungal biolog

SUBMITTER: James MR 

PROVIDER: S-EPMC10871163 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature