Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.

ABSTRACT: The accurate estimation of the distribution of fitness effects (DFE) of new mutations is critical for population genetic inference but remains a challenging task. While various methods have been developed for DFE inference using the site frequency spectrum of putatively neutral and selected sites, their applicability in species with diverse life history traits and complex demographic scenarios is not well understood. Selfing is common among eukaryotic species and can lead to decreased effective recombination rates, increasing the effects of selection at linked sites, including interference between selected alleles. We employ forward simulations to investigate the limitations of current DFE estimation approaches in the presence of selfing and other model violations, such as linkage, departu

SUBMITTER: Daigle A 

PROVIDER: S-EPMC10871249 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature