Neural signatures of opioid-induced risk-taking behavior in the prelimbic prefrontal cortex.

ABSTRACT: Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of cat odor (Risk-Takers) or exhibited increased avoidance (Risk-Avoiders), as reve

SUBMITTER: Quave CB 

PROVIDER: S-EPMC10871263 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature