Tension-induced adhesion mode switching: the interplay between focal adhesions and clathrin-containing adhesion complexes.

ABSTRACT: Integrin-based adhesion complexes are crucial in various cellular processes, including proliferation, differentiation, and motility. While the dynamics of canonical focal adhesion complexes (FAs) have been extensively studied, the regulation and physiological implications of the recently identified clathrin-containing adhesion complexes (CCACs) are still not well understood. In this study, we investigated the spatiotemporal mechanoregulations of FAs and CCACs in a breast cancer model. Employing single-molecule force spectroscopy coupled with live-cell fluorescence microscopy, we discovered that FAs and CCACs are mutually exclusive and inversely regulated complexes. This regulation is orchestrated through the modulation of plasma membrane tension, in combination with distinct modes of actom

SUBMITTER: Djakbarova U 

PROVIDER: S-EPMC10871318 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature