The impact of non-neutral synonymous mutations when inferring selection on non-synonymous mutations.

ABSTRACT: The distribution of fitness effects (DFE) describes the proportions of new mutations that have different effects on reproductive fitness. Accurate measurements of the DFE are important because the DFE is a fundamental parameter in evolutionary genetics and has implications for our understanding of other phenomena like complex disease or inbreeding depression. Current computational methods to infer the DFE for nonsynonymous mutations from natural variation first estimate demographic parameters from synonymous variants to control for the effects of demography and background selection. Then, conditional on these parameters, the DFE is then inferred for nonsynonymous mutations. This approach relies on the assumption that synonymous variants are neutrally evolving. However, some evidence points

SUBMITTER: Zurita AMI 

PROVIDER: S-EPMC10871344 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature