Stressor-evoked brain activity, cardiovascular reactivity, and subclinical atherosclerosis in midlife adults.

ABSTRACT:

Background

Cardiovascular responses to psychological stressors have been separately associated with preclinical atherosclerosis and hemodynamic brain activity patterns across different studies and cohorts; however, what has not been established is whether cardiovascular stress responses reliably link indicators of stressor-evoked brain activity and preclinical atherosclerosis that have been measured in the same individuals. Accordingly, the present study used cross-validation and predictive modeling to test for the first time whether stressor-evoked systolic blood pressure (SBP) responses statistically mediated the association between concurrently measured brain activity and a vascular marker of preclinical atherosclerosis in the carotid arteries.

Methods

624 midlife adults

SUBMITTER: Rasero J 

PROVIDER: S-EPMC10871357 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature