Application of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T.

ABSTRACT:

Introduction

With nicotine dependence being a significant healthcare issue worldwide there is a growing interest in developing novel therapies and diagnostic aids to assist in treating nicotine addiction. Glutamate (Glu) plays an important role in cognitive function regulation in a wide range of conditions including traumatic brain injury, aging, and addiction. Chemical exchange saturation transfer (CEST) imaging via ultra-high field MRI can image the exchange of certain saturated labile protons with the surrounding bulk water pool, making the technique a novel tool to investigate glutamate in the context of addiction. The aim of this work was to apply glutamate weighted CEST (GluCEST) imaging to study the dorsal anterior cingulate cortex (dACC) in a small population of smokers and

SUBMITTER: Jacobs PS 

PROVIDER: S-EPMC10871471 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature