Organomegalies as a predictive indicator of leukemia cutis in patients with acute myeloid leukemia.

ABSTRACT:

Background

Leukemia cutis (LC) is an extramedullary acute myeloid leukemia (AML) infiltrate. No previous study has described the clinical characteristics and outcomes of Thai patients diagnosed with AML with LC.

Materials and methods

We conducted a 7-year retrospective case-control study on Thai AML patients at Siriraj Hospital from November 2013 to July 2020. Patients were divided into LC and non-LC groups. Initial clinical presentations and laboratory findings were examined to identify LC-associated factors. Overall survival (OS) and relapse-free survival (RFS) were assessed. Pathological tissues underwent re-evaluation to validate the LC diagnoses.

Results

The study included 159 patients in a 2:1 ratio (106 non-LC and 53 LC). The LC group had a mean ± SD age of 54.

SUBMITTER: Kanitthamniyom C 

PROVIDER: S-EPMC10871476 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature