Neuroadrenergic activation in obstructive sleep apnoea syndrome: a new selected meta-analysis - revisited.

ABSTRACT:

Background

Neuroadrenegic overdrive occurs in obstructive sleep apnoea syndrome (OSAS). However, the small sample size of the microneurographic studies, heterogeneity of the patients examined, presence of comorbidities, represented major weaknesses not allowing to precisely define the main features of the phenomenon, particularly in nonobese patients.

Objective

This meta-analysis detected 14 microneurographic studies based on muscle sympathetic nerve activity (MSNA) quantification in uncomplicated OSAS of different clinical severity.

Methods

The evaluation was extended to the relationships of MSNA with heart rate, anthropometric and blood pressure values, metabolic variables, apnoea-hypopnea index and oxygen saturation.

Results

MSNA is activated markedly and al

SUBMITTER: Biffi A 

PROVIDER: S-EPMC10871617 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature