Effects of severe obesity and sleeve gastrectomy on cortical thickness in adolescents.

ABSTRACT:

Objective

Neurocognitive differences in pediatric obesity may be underpinned by cortical structural alterations. Differences in cortical thickness associated with severe obesity were examined, and preliminary evidence was sought for changes following vertical sleeve gastrectomy (VSG).

Methods

A total of 18 adolescents with severe obesity (OB) and 17 without obesity (nOB), aged 14 to 21, underwent T1-weighted structural magnetic resonance imaging. A subset was scanned twice 5 months apart to compare cortical thickness following VSG (n = 6) with two control groups: wait-listed (n = 9) and nOB (n = 12).

Results

At baseline, OB had a thinner cortex than nOB in motor and superior parietal cortices. At follow-up, VSG adolescents lost weight, the wait-listed group gained wei

SUBMITTER: Rajan L 

PROVIDER: S-EPMC10871717 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature