Perinatal exposures and adolescence overweight: The role of shared maternal-offspring pathways.

ABSTRACT:

Background and aims

Early life exposures affect offspring health across the life-course. We aimed to examine whether prevalent perinatal exposures and obstetric complications are independently associated with offspring overweight in adolescence. We then assessed whether shared maternal-offspring pathways drive the association of perinatal exposures with offspring overweight.

Methods

Using data from the Jerusalem Perinatal Study birth cohort, two perinatal scores were constructed: obstetric complications (OC) and prevalent perinatal exposures (PPE) scores. PPE score, generated by principal component analysis, included three primary components. Logistic regressions were used to assess associations of scores with offspring overweight, with and without adjustment for maternal li

SUBMITTER: Shapiro I 

PROVIDER: S-EPMC10872218 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature