Experiences of racial discrimination and adverse gene expression among black individuals in a level 1 trauma center sample.

ABSTRACT: Up to 40 % of individuals who sustain traumatic injuries are at risk for posttraumatic stress disorder (PTSD) and the conditional risk for developing PTSD is even higher for Black individuals. Exposure to racial discrimination, including at both interpersonal and structural levels, helps explain this health inequity. Yet, the relationship between racial discrimination and biological processes in the context of traumatic injury has yet to be fully explored. The current study examined whether racial discrimination is associated with a cumulative measure of biological stress, the gene expression profile conserved transcriptional response to adversity (CTRA), in Black trauma survivors. Two-weeks (T1) and six-months (T2) post-injury, Black participants (N = 94) provided a blood specimen and com

SUBMITTER: Bird CM 

PROVIDER: S-EPMC10872243 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature