Kv3.1 Voltage-gated Potassium Channels Modulate Anxiety-like Behaviors in Female Mice.

ABSTRACT: Inhibitory parvalbumin (PV) interneurons regulate the activity of neural circuits within brain regions involved in emotional processing, including the prefrontal cortex (PFC). Recently, rodent studies have implicated a stress-induced increase in prefrontal PV neuron activity in the development of anxiety behaviors, particularly in females. However, the mechanisms through which stress increases activity of prefrontal PV neurons remain unknown. The fast-spiking properties of PV neurons in part come from their expression of voltage-gated potassium (K+) ion channels, particularly Kv3.1 channels. We therefore suggest that stress-induced changes in Kv3.1 channels contribute to the appearance of an anxious phenotype following chronic stress in female mice. Here, we first showed that unpredictable

SUBMITTER: Page CE 

PROVIDER: S-EPMC10872248 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature